A Guide to Pregnancy and Psychiatric Meds
If you’re pregnant or planning to become pregnant and take psychiatric medication, you’re likely facing one of the most difficult decisions in mental health care: Should I stay on my medication during pregnancy?
It’s a question many women struggle with—and understandably so. You want to protect your baby, but you also need to stay well. The truth is, there is no one-size-fits-all answer. The safest and healthiest choice depends on your diagnosis, history, current symptoms, and the specific medication involved. The good news is: you don’t have to make this decision alone—or without information.
The Risks of Untreated Mental Health Conditions
While concerns about medication side effects are valid, it’s also important to recognize the risks of not treating a mental health condition during pregnancy. Untreated depression, anxiety, bipolar disorder, or schizophrenia can lead to:
- Poor nutrition or sleep
- Missed prenatal care
- Increased substance use
- Preterm birth or low birth weight
- Difficulty bonding with the baby
- Higher risk of postpartum relapse or psychosis
In many cases, continuing medication is the safer choice for both mother and baby—especially when symptoms are severe or have previously led to hospitalization, suicidal thoughts, or impaired functioning.
What Makes These Decisions So Complex?
If you’re currently taking a psychiatric medication, the goal is to weigh the potential risks of continuing treatment against the known risks of untreated illness. This conversation is never one-size-fits-all, and it should involve both your prescribing psychiatrist and your OB-GYN or maternal-fetal medicine specialist.
You may wonder:
- What trimester is the safest (or riskiest) time to take this medication?
- Are there safer alternatives that work similarly?
- What’s the lowest effective dose?
- Has this medication been studied in pregnancy or breastfeeding?
- What is my personal risk of relapse if I stop treatment?
These are excellent and important questions—but often, there aren’t clear-cut answers. Many psychiatric medications have limited data in pregnancy, and outcomes can be difficult to predict because every person’s psychiatric history and physiology are different. What works well and safely for one patient may not be appropriate for another.
That’s why treatment decisions in pregnancy are best approached as shared, evolving conversations, not fixed answers. Your providers will help interpret the available evidence while also factoring in your individual mental health needs, history of medication response, and personal preferences.
Some medications, like sertraline or lamotrigine, are commonly used in pregnancy and may be continued when the benefits outweigh potential risks. Others, like valproic acid or paroxetine, are more likely to be avoided if alternatives are available. But even then, decisions aren’t always black and white—they’re about choosing the safest and most effective path forward for you.
Using Trusted Tools to Guide the Conversation
To support these important conversations, it can be helpful to review evidence-based resources that summarize what we know about psychiatric medications in pregnancy and breastfeeding. One trusted resource used by healthcare providers across the country is MotherToBaby.
What Is MotherToBaby?
MotherToBaby is a free, evidence-based service provided by the Organization of Teratology Information Specialists (OTIS). Staffed by experts in prenatal development, birth defects, and medication safety, the organization offers accurate, research-backed information about how medications, supplements, and environmental exposures may affect pregnancy and lactation.
MotherToBaby is widely used by OB-GYNs, psychiatrists, pediatricians, and pharmacists to support shared decision-making with patients.
How MotherToBaby Fact Sheets Can Support Your Medication Decisions
If you’re taking psychiatric medications such as antidepressants, mood stabilizers, or antipsychotics, it’s important to understand how those medications may affect pregnancy, birth, or nursing. MotherToBaby’s fact sheets translate the scientific research into plain language, helping you prepare for a more informed discussion with your doctor.
Each fact sheet includes:
- Whether the medication has been studied in pregnancy or breastfeeding
- Known or potential risks to the baby, including trimester-specific concerns
- Breastfeeding safety and neonatal considerations
- Effects on fertility or pregnancy outcomes
- How to use the information to guide conversations with your providers
Fact sheets are available in English and Spanish, and updated regularly as new research becomes available. You can view the full collection at MotherToBaby.org/fact-sheets-parent, or scroll down for a curated list of commonly prescribed psychiatric medications.
How to Make an Informed Decision
Making the right decision means gathering reliable information and partnering closely with your healthcare providers. Here are steps you can take to feel more informed and empowered:
Review your mental health history. If you’ve had prior relapses when stopping medication, this weighs heavily in favor of continuing treatment.
Ask your providers to explain the evidence. Risk is often relative—what sounds concerning on paper may not be significant in real life.
Learn about timing. Some medications may carry higher risk in the first trimester, while others are more concerning later in pregnancy or during breastfeeding.
Use trusted, evidence-based resources. Tools like MotherToBaby fact sheets can help you understand potential risks and prepare thoughtful questions.
Don’t make sudden changes. Never stop or reduce your medication without medical guidance. Doing so may increase the risk of withdrawal or relapse.
Final Thoughts
Pregnancy is a time of transformation—but it doesn’t have to come at the expense of your mental health. If you’re taking psychiatric medication, you don’t have to choose between your well-being and your baby’s safety. With the right support, careful planning, and access to accurate information, many women are able to maintain treatment and have healthy pregnancies.
Use the resources available to you—trusted healthcare providers, evidence-based fact sheets, and your own personal history—to make a decision that feels right for you.
Scroll down to view our curated list of MotherToBaby fact sheets for commonly used psychiatric medications.
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