Managing Mental Illness During Pregnancy
Pregnancy is a transformative time, but for many women, it also overlaps with the need to manage mental health conditions such as depression, anxiety, bipolar disorder, or OCD. In fact, a significant number of pregnancies involve women with pre-existing or newly emerging psychiatric illnesses. An estimated 500,000 pregnancies in the United States each year involve women who have, or who will develop, a psychiatric illness during pregnancy. This raises important and often difficult questions about the safety of psychiatric medications during this sensitive time. Understanding the potential risks and benefits—both for the mother and the developing baby—is essential in making informed, individualized treatment decisions.
Why Treating Maternal Mental Health Matters
Maintaining mental health during pregnancy is not just important—it’s essential for both maternal and fetal well-being. Untreated or poorly managed psychiatric conditions can lead to significant complications that extend beyond emotional distress. These may include reduced adherence to prenatal care, inadequate nutrition, increased use of alcohol or tobacco, and a higher risk of preterm birth and low birth weight. Mental health symptoms can also interfere with the ability to prepare for motherhood and may contribute to challenges in bonding with the baby after birth.
For women with more severe conditions—such as bipolar disorder, schizophrenia, or recurrent major depression—the risks associated with stopping psychiatric medications often outweigh the potential risks of continuing them. Sudden discontinuation is especially discouraged, as it may lead to withdrawal symptoms or trigger relapse, both of which can pose risks to both mother and baby. A carefully monitored, individualized treatment plan is the safest path forward for ensuring the health of both the parent and the child.
Managing Specific Psychiatric Conditions During Pregnancy
While every situation is unique, research offers valuable guidance for managing specific mental health conditions during pregnancy and postpartum. Below are key considerations for several common diagnoses.
Major Depression
Depression affects up to 16% of pregnant women, and up to 70% experience symptoms. Discontinuing antidepressants during pregnancy leads to relapse in nearly 70% of cases. Untreated depression—especially in the second and third trimesters—has been linked to premature birth, low birth weight, and postnatal complications.
- SSRIs and SNRIs are often used during pregnancy. While most carry a low risk of birth defects, late-pregnancy exposure can sometimes cause short-term neonatal symptoms such as tremor, irritability, or poor feeding (Postnatal Adaptation Syndrome).
- Paroxetine (Paxil) should be avoided due to possible increased risk of cardiac malformations.
- Most SSRIs and tricyclic antidepressants are considered compatible with breastfeeding, though data are limited.
Bipolar Disorder
Women with bipolar disorder face a 32–67% risk of postpartum relapse, and depressive episodes are more likely to recur in future pregnancies. The decision to use mood stabilizers must carefully balance maternal risk of relapse against fetal risks.
Lithium
- Linked to congenital heart defects when used in the first trimester.
- May still be appropriate for women with severe, recurrent episodes.
- Monitoring lithium levels throughout pregnancy is essential.
- Breastfeeding while on lithium is not generally recommended due to limited safety data.
Antiepileptic Mood Stabilizers
- Valproic acid is associated with neural tube defects and should be avoided.
- Carbamazepine carries some risk for birth defects but may be used cautiously.
- Lamotrigine appears safer and may be an option for maintenance therapy.
Anxiety Disorders
Anxiety disorders are the most common psychiatric condition in pregnancy. While some benzodiazepines are linked to minor birth defect risks, most do not carry major teratogenic risks.
- Late-pregnancy use may result in floppy infant syndrome or withdrawal symptoms in the newborn.
- Benzodiazepines should be used sparingly and avoided close to delivery when possible.
- During breastfeeding, they are usually safe unless the infant has metabolic concerns.
Schizophrenia
Untreated schizophrenia can result in serious complications such as preterm birth, low birth weight, and postnatal complications, and increases the risk of poor maternal outcomes.
- Atypical antipsychotics like olanzapine and risperidone are commonly used, but long-term safety data during pregnancy are limited.
- Typical antipsychotics such as haloperidol and chlorpromazine have a longer track record of use in pregnancy and may be preferred in some cases.
- Breastfeeding while on antipsychotics requires careful monitoring, and developmental data are still emerging.
How to Decide Whether to Take Medication During Pregnancy
The best time to discuss psychiatric medications and pregnancy is before you conceive, but that’s not always possible. As soon as you’re planning to become pregnant—or if you’ve just found out you’re expecting—talk to your psychiatrist and OB/GYN.
Together, you can review:
- Severity of your symptoms
- Your history with medication and relapse
- Potential medication adjustments
- Safer alternatives or non-medication options
- The minimal effective dose needed for stability
In most cases, completely stopping medication is not necessary, but adjustments may be helpful. The goal is to manage symptoms effectively while minimizing risk to the developing baby.
Ongoing Monitoring and Shared Decision-Making
Managing psychiatric conditions during pregnancy requires collaboration between you and your healthcare team. Regular monitoring helps ensure that both you and your baby are staying healthy.
Be sure to:
- Report any new symptoms or side effects
- Keep up with both psychiatric and prenatal appointments
- Ask questions about your medication’s safety and alternatives
- Never stop or adjust your medication without medical guidance
Beyond Medication: Complementary Support Options
While medication may be necessary for many women, other forms of support can also make a big difference:
Therapy: CBT and interpersonal therapy are effective for depression and anxiety.
Lifestyle habits: Exercise (with OB approval), good nutrition, and consistent sleep.
Social support: Stay connected with friends, family, or pregnancy support groups.
Get Support for Medication Decisions in Pregnancy in New Jersey
Psychiatric medication use during pregnancy is a deeply personal decision that should be made with the guidance of your providers. While some medications carry risks, untreated mental illness also poses serious dangers to both mother and baby.
At Kolli Psychiatric Associates, we are here to support you with individualized care, evidence-based recommendations, and a collaborative approach to treatment.
You don’t have to face this journey alone.
Resources
- https://www.aafp.org/pubs/afp/issues/2008/0915/p772.html
- https://americanpregnancy.org/healthy-pregnancy/medication/medication-and-pregnancy
- https://www.aafp.org/pubs/afp/issues/2002/0815/p629.html
- Cohen LS, Rosenbaum JF. Psychotropic drug use during pregnancy: weighing the risks. J Clin Psychiatry. 1998;59(suppl 2):18-28.
- Wisner KL, Gelenberg AJ, Leonard H, Zarin D, Frank E. Pharmacologic treatment of depression during pregnancy. JAMA. 1999;282:1264-9.
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